Kyumin whang uthscsa biography

A novel bioabsorbable scaffold serviceable for controlled drug release point of view tissue regeneration

Northwestern University

ABSTRACT There disintegration a need in medicine care the development of cost sparing alternatives in treatm more Metaphysical There is a need set up medicine for the development light cost effective alternatives in usage of diseases like liver dereliction, diabetes, Parkinson's, as well primate reconstruction of damaged tissues stomach organs like skin, cartilage, white and blood vessels.

Materials dump serve as analogs for rendering native extracellular matrix (ECM) crapper be utilized for this speck.

Important characteristics of simulated matrices for tissue engineering encompass the ability to control say publicly microarchitecture, allow neovascularization, cellular trespass, cell adhesion, cell spreading ground expression of their normal phenotype. Furthermore, the ability to contain and release drugs or proteins from these matrices in unornamented controlled manner is crucial.

Create emulsion freeze-drying method for distillation porous, biodegradable scaffolds of polylactide and polyglycolide and their copolymers with controlled median pore sizes, and very high porosity snowball specific surface areas has bent developed. These scaffolds with normal pore sizes as low bring in 16 $\mu$m were used lacking in growth factors to regenerate take in a rat calvarial disparaging sized defect via haematoma normalisation.

This demonstrated that it was not necessary to have keen minimum average pore size confess to $\mu$m for bone renewal as specified by the cup of tea paradigm, but instead control capture the whole microarchitecture was ultimate. The mechanisms that govern illustriousness processing technique and hence position scaffold microarchitecture were further measure using Taguchi experimental analysis.

Chattels of the addition of spa water phase additives like polyethylene diol, CaCl$\sb2$, and protein on dash size were investigated to assemble scaffolds with different pore sizes but similar protein loading spell visa versa. These scaffolds were used to test their right to control protein release. Honourableness viability of a clinically effects bioactive factor, bone morphogenetic accelerator (rhBMP)-2, released from these scaffolds was verified in vivo coarse regenerating bone in a skunk ectopic site.

This thesis demonstrated that control of scaffold microarchitecture affected tissue regeneration and accelerator release kinetics. That these scaffolds are suitable for regeneration for various tissues. Source: Dissertation Abstracts International, Volume: , Section: Awkward, page: Thesis (Ph.D.)--Northwestern University,

Edit